Glaucoma Medicines

 

These include:

prostaglandin analogs   –  work by increasing the outflow of fluid from the eye.

beta blockers                     – work by decreasing production of fluid

alpha agonists                   – work to both decrease production of fluid and increase drainage

and carbonic anhydrase inhibitors  –    reduce eye pressure by decreasing the production of intraocular fluid.

Combination drugs

Older medications, the cholinergic agonists (such as pilocarpine) are not commonly used these days due to their side effects.

Types of Glaucoma Eye Drops

Prostaglandin analogs include

Xalatan® (latanoprost),

Lumigan® (bimatoprost),

Travatan Z® (Travoprost),

and Zioptan™ (tafluprost).

 

They have few systemic side effects but are associated with changes to the eye itself, including change in iris color and growth of eyelashes.

Depending on the individual, one of these preparations may be more effective and produce fewer side effects.

Latanoprost and some formulations of bimatoprost are now available in generic form.

Tafluprost is a preservative-free prostaglandin analog.

Beta blockers such as timolol are the second most often used class of medication. They are available in generic form and, therefore, may be less expensive. Timolol is also available in a preservative-free formulation. Systemic side effects of beta blockers can be minimized by closing the eyes following application or using a technique called punctal occlusion that prevents the drug from entering the tear drainage duct and systemic circulation.

Alpha agonists

Alphagan®P (brimonidine)

Iopidine®] .

 

Alphagan P has a purite preservative that breaks down into natural tear components and may be better tolerated in people who have allergic reactions to preservatives in other eye drops. Alphagan is available in a generic form.

Carbonic anhydrase inhibitors (CAIs) 

These are available as eye drops

[Trusopt® (dorzolamide),

Azopt® (brinzolamide)] as well as

pills [Diamox (acetazolamide) and Neptazane® (methazolamide)].

Except for brinzolamide, all CAIs are available in generic form.

Combined medications can offer an alternative for patients who need more than one type of medication.

In addition to the convenience of using one eyedrop bottle instead of two, there is decreased exposure to preservatives.

They nearly always  include a beta-blocker (timolol).

Cosopt® is a combination of a beta blocker (timolol) and a carbonic anhydrase inhibitor (dorzolamide) and is available in generic form and also as a preservative-free formulation (Cosopt® PF).

Azarga  Active Substance:  timolol  brinzolamide

 

2 contain an alpha agonist  (brimonidine) with a betablocker (combigan) or without.

Combigan® combines beta blocker (timolol) with an alpha agonist (brimonidine).

Simbrinza® is a beta blocker-free combination medication consisting of (CAI) brinzolamide and (alpha-blocker) brimonidine.

TOPICAL GLAUCOMA DRUGS
BRAND NAME GENERIC NAME MANUFACTURER CONCENTRATION BOTTLE SIZE
Beta Blockers      
Betagan levobunolol hydrochloride Allergan, and generic 0.25% 5ml, 10ml
  0.50% 5ml, 10ml, 15ml
Betimol timolol hemihydrate Akorn 0.25% 5ml
    0.50% 5ml, 10ml, 15ml
Betoptic-S betaxolol hydrochloride Alcon 0.25% 5ml, 10ml, 15ml
Istalol timolol maleate Bausch + Lomb 0.50% 2.5ml, 5ml
Timoptic timolol maleate Valeant Ophthalmics, 0.25% 5ml, 10ml, 15ml
  and generic 0.50% 5ml, 10ml, 15ml
Timoptic (preservative-free) timolol maleate Valeant Ophthalmics 0.25% unit-dose
    0.50% unit-dose
Timoptic-XE timolol maleate Valeant Ophthalmics, 0.25% 2.5ml, 5ml
  and generic 0.50% 2.5ml, 5ml
TIOPEX timolol 1 mg/g, eye gel in single-dose container     
Prostaglandin Analogs      
Bimatoprost  bimatoprost generic 0.03% 2.5ml, 5ml, 7.5ml
Lumigan bimatoprost Allergan 0.01% 2.5ml, 5ml, 7.5ml
 

Travatan Z travoprost

Alcon 0.00% 2.5ml, 5ml
Travoprost travoprost generic 0.00% 2.5ml, 5ml
Xalatan latanoprost Pfizer, + generic 0.01%
Monopost latanoprost Thea Pharmaceuticals Ltd 1 ml eye drops solution contains 50 micrograms of latanoprost. One drop contains approximately 1.5 micrograms of latanoprost.
Zioptan tafluprost Akorn 0.00% unit-dose
Alpha Agonists      
Alphagan P brimonidine Allergan 0.1%, 0.15% 5ml, 10ml, 15ml
Brimonidine brimonidine generic 0.15%, 0.2% 5ml, 10ml, 15ml
Carbonic Anhydrase Inhibitors      
Azopt brinzolamide Alcon 1% 5ml, 10ml, 15ml
Trusopt dorzolamide Merck, + generic 2% 5ml, 10ml
Combination Glaucoma Medications
Combigan brimonidine/timolol Allergan 0.2%/0.5% 5ml, 10ml
Cosopt dorzolamide/timolol Akorn, + generic 2%/0.5% 5ml, 10ml
Cosopt PF dorzolamide/timolol Akorn 2%/0.5% unit-dose
Simbrinza brinzolamide/brimonidine Alcon 1%/0.2% 8ml

Comments are closed.